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CS-W001157 4
Total: USD 88.00

4-Chloro-3-fluorophenylboronic acid

  • CAS No. 137504-86-0

  • Cat. No. CS-D1011
  • Purity≥98%
  • MDL No.MFCD01319010

*For research and further manufacturing use only, not for direct human use.

4-Chloro-3-fluorophenylboronic acid|CS-D1011

Structure of 137504-86-0

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General Information

  • CAS No. 137504-86-0
  • Cat. No. CS-D1011
  • Purity ≥98%
  • MDL No. MFCD01319010
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BClFO₂
  • Molecular Weight 174.37
  • Synonym(s) None
  • SMILES FC1=CC(B(O)O)=CC=C1Cl

Description

L-Cysteine ethyl ester hydrochloride is widely used in food additive, cosmetic, pharmaceutical area.

Application

4-Chloro-3-fluorophenylboronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. Its orthogonal halogen reactivity allows sequential functionalization, while the boronic acid group offers excellent bench stability and compatibility with diverse reaction matrices. This reagent facilitates the synthesis of complex fluorinated aromatics and heterocyclic scaffolds commonly found in pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • WO2004/33435 A1, ; Page 15-16 ; WO 2004/033435 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.1589
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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