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CS-W001157 4
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6-Bromo-3-(trifluoromethyl)-1H-indazole

  • CAS No. 1374258-63-5

  • Cat. No. CS-0041314
  • Molecule weight265.03
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3-(trifluoromethyl)-1H-indazole|CS-0041314

Structure of 1374258-63-5

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General Information

  • CAS No. 1374258-63-5
  • Cat. No. CS-0041314
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄BrF₃N₂
  • Molecular Weight 265.03
  • Synonym(s) 6-bromo-3-(trifluoromethyl)-2H-indazole
  • SMILES FC(C1=NNC2=C1C=CC(Br)=C2)(F)F

Description

6-Bromo-3-(trifluoromethyl)-1H-indazole is a sterically hindered, electron-deficient heterocycle featuring a bromine at the 6-position and a trifluoromethyl group at the 3-position. This combination enhances metabolic stability and facilitates downstream functionalization via cross-coupling reactions. The molecule exhibits excellent bench-stability and solubility in common organic solvents, enabling seamless integration into medicinal chemistry and materials synthesis workflows.

Application

6-Bromo-3-(trifluoromethyl)-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle and electron-deficient indazole core. The trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the compound exhibits good bench stability and compatibility with standard purification methods. It functions effectively in the synthesis of heterocyclic scaffolds relevant to pharmaceutical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   3.3442
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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