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8-Fluoronaphthalen-1-amine

  • CAS No. 13720-52-0

  • Cat. No. CS-0379786
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Fluoronaphthalen-1-amine|CS-0379786

Structure of 13720-52-0

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General Information

  • CAS No. 13720-52-0
  • Cat. No. CS-0379786
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈FN
  • Molecular Weight 161.18
  • Synonym(s) 8-Fluoro-1-naphthalenamine
  • SMILES FC1=CC=CC2=C1C(N)=CC=C2

Description

8-Fluoronaphthalen-1-amine features a fluorinated naphthalene core with an amino group at the 1-position, delivering enhanced electron-donating character and improved metabolic stability. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into functional materials.

Application

8-Fluoronaphthalen-1-amine serves as a valuable building block for the synthesis of functionalized naphthalene derivatives, enabling direct incorporation of both amine and fluorine functionalities in a single scaffold. Its reactivity is well-suited for Suzuki-Miyaura coupling, electrophilic substitution, and amide bond formation, with the fluorine substituent providing orthogonal reactivity and enhanced metabolic stability. The compound exhibits good bench stability and facilitates straightforward purification, making it ideal for medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • Zhu, Zhijian; Colbry, Norm L.; Lovdahl, Mark; Mennen, Kenneth E.; Acciacca, Alison; Beylin, Vladimir G.; Clark, Jerry D.; Belmont, Daniel T. Organic Process Research and Development, 2007 , vol. 11, # 5 p. 907 - 909
  • Route2
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      8-Fluoronaphthalen-1-amine|CS-0379786
      13720-52-0

    References

    • Bassilios,H.F. et al. Bulletin des Societes Chimiques Belges, 1966 , vol. 75, p. 577 - 581
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      3229-89-8
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    • In-stock
      8-Fluoronaphthalen-1-amine|CS-0379786
      13720-52-0

    References

    • Bassilios,H.F. et al. Bulletin des Societes Chimiques Belges, 1966 , vol. 75, p. 577 - 581

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.5611
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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