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1-(tert-Butoxycarbonyl)-2-oxopyrrolidine-3-carboxylic acid

  • CAS No. 1370018-07-7

  • Cat. No. CS-0372634
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-2-oxopyrrolidine-3-carboxylic acid|CS-0372634

Structure of 1370018-07-7

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General Information

  • CAS No. 1370018-07-7
  • Cat. No. CS-0372634
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₅
  • Molecular Weight 229.23
  • Synonym(s) 1,3-Pyrrolidinedicarboxylic acid, 2-oxo-, 1-(1,1-dimethylethyl) ester
  • SMILES O=C(N1C(C(C(O)=O)CC1)=O)OC(C)(C)C

Description

This protected pyrrolidone derivative features a tert-butoxycarbonyl group enabling stable incorporation into peptide synthesis. The oxopyrrolidine core provides a rigid, electron-deficient scaffold ideal for conformational control in bioactive molecule design.

Application

1-(tert-Butoxycarbonyl)-2-oxopyrrolidine-3-carboxylic acid serves as a versatile building block in peptide and heterocyclic synthesis, enabling efficient access to pyrrolidinone scaffolds. The protected amine and ketone functionalities offer orthogonal reactivity, facilitating sequential transformations in multistep syntheses. Its bench-stable nature and compatibility with standard coupling conditions make it ideal for solid-phase and solution-phase applications in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   83.91
  • LogP   0.8546
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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