5-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one

Name: 5-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1367905-79-0
Cat. No. CS-0057198
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one|CS-0057198

Structure of 1367905-79-0

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Description

5-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one features a brominated isoquinolinone core with a methyl group at the 2-position, offering enhanced electron-withdrawing character and improved solubility in organic solvents. This scaffold serves as a key intermediate in the synthesis of bioactive alkaloids and pharmaceutical candidates, particularly where halogenation supports downstream coupling reactions. The bench-stable, moisture-tolerant structure enables reliable use in multi-step transformations under standard conditions.

Application

5-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one serves as a versatile scaffold for the synthesis of isoquinoline-based bioactive molecules. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the ketone functionality supports nucleophilic additions and condensation processes. The 2-methyl group enhances stability and modulates reactivity, facilitating straightforward purification and functionalization. This compound functions effectively in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

General Information

CAS No. 1367905-79-0
Cat. No. CS-0057198
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈BrNO
Molecular Weight 238.08
Synonym(s) 5-broMo-2-Methylisoquinolin-1(2H)-one
SMILES O=C1N(C)C=CC2=C1C=CC=C2Br

Computational Chemistry Data

TPSA 22
LogP 2.301
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Isoquinoline compounds

Key Words

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5-Bromo-2-methyl-1,2-dihydroisoquinolin-1-one

CAS No. 1367905-79-0

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