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CS-W001157 4
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3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine

  • CAS No. 1365957-74-9

  • Cat. No. CS-0435657
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine|CS-0435657

Structure of 1365957-74-9

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General Information

  • CAS No. 1365957-74-9
  • Cat. No. CS-0435657
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅BrN₄
  • Molecular Weight 177.00
  • Synonym(s) None
  • SMILES NC1=NC(Br)=NN1C

Description

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine features a brominated triazole core with a methylated nitrogen at the 1-position, enabling direct incorporation into heterocyclic scaffolds. This bench-stable compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor and antifungal agent development.

Application

3-Bromo-1-methyl-1H-1,2,4-triazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to triazolyl-based heterocycles via cross-coupling and nucleophilic substitution reactions. The bromo group facilitates palladium-catalyzed transformations, while the 1-methyl-1H-1,2,4-triazole scaffold offers enhanced metabolic stability and hydrogen-bonding capacity. This compound exhibits good bench stability, simplifies purification, and demonstrates broad functional group tolerance, making it well-suited for iterative synthesis of bioactive molecules and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.73
  • LogP   0.1598
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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