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(R)-2,2'-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl

  • CAS No. 1365531-84-5

  • Cat. No. CS-0087264
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(R)-2,2'-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4',6,6'-tetramethoxy)-1,1'-biphenyl|CS-0087264

Structure of 1365531-84-5

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General Information

  • CAS No. 1365531-84-5
  • Cat. No. CS-0087264
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₈H₂₈F₂₄O₄P₂
  • Molecular Weight 1186.64
  • Synonym(s) (R)-2,2'-Bis[bis(3,5-trifluoroMethylphenyl)phosphino]-4,4',6,6'-tetraMethoxybiphenyl (R)-BTFM-Garphos
  • SMILES COC1=CC(OC)=CC([P]C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=C1C3=C(OC)C=C(OC)C=C3[P]C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Description

(R)-2,2'-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4',6,6'-tetramethoxy-1,1'-biphenyl is a sterically hindered, electron-rich phosphine ligand featuring two bulky 3,5-trifluoromethylphenyl groups and four methoxy substituents that enhance solubility and stability. This configuration promotes efficient metal coordination in catalytic applications, particularly in palladium-catalyzed cross-coupling reactions.

Application

(R)-2,2'-Bis[bis(3,5-trifluoromethylphenyl)phosphino]-4,4',6,6'-tetramethoxy-1,1'-biphenyl serves as a sterically demanding, electron-rich phosphine ligand that enables efficient palladium-catalyzed cross-coupling reactions. Its ortho-methoxy groups enhance solubility and stability, while the trifluoromethyl-substituted arylphosphino moieties promote high catalytic activity in Suzuki-Miyaura and Negishi couplings. Ideal for challenging substrates and scale-up applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P304+P340-P405-P501

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   8.7218
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   9

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