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tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate

  • CAS No. 1363381-61-6

  • Cat. No. CS-0047445
  • Molecule weight254.37
  • Purity≥97%
  • MDL No.MFCD22033481

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate|CS-0047445

Structure of 1363381-61-6

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General Information

  • CAS No. 1363381-61-6
  • Cat. No. CS-0047445
  • Purity ≥97%
  • MDL No. MFCD22033481
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₆N₂O₂
  • Molecular Weight 254.37
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC2(C1)CCC(N)CC2

Description

tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate is a sterically hindered spirocyclic amine scaffold featuring a pendant primary amine and a bench-stable tert-butyl ester group. This configuration enables direct functionalization in late-stage diversification, supporting efficient access to complex nitrogen-rich architectures in medicinal chemistry campaigns.

Application

tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry, enabling efficient access to complex nitrogen-containing heterocycles. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating modular derivatization via coupling, reductive amination, or cyclization. Bench-stable and readily purified, it supports scalable synthesis of bioactive molecules in drug discovery programs.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   2.5149
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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