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2-Boc-5-oxa-2,8-diaza-spiro[3.5]nonan-7-one

  • CAS No. 1363381-20-7

  • Cat. No. CS-0028386
  • Purity≥95%
  • MDL No.MFCD22566166

*For research and further manufacturing use only, not for direct human use.

2-Boc-5-oxa-2,8-diaza-spiro[3.5]nonan-7-one|CS-0028386

Structure of 1363381-20-7

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General Information

  • CAS No. 1363381-20-7
  • Cat. No. CS-0028386
  • Purity ≥95%
  • MDL No. MFCD22566166
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈N₂O₄
  • Molecular Weight 242.27
  • Synonym(s) tert-butyl 7-oxo-5-oxa-2,8-diazaspiro[3.5]nonane-2-carboxylate
  • SMILES CC(C)(C)OC(N1CC2(CNC(CO2)=O)C1)=O

Description

2-Boc-5-oxa-2,8-diaza-spiro[3.5]nonan-7-one is a rigid, nitrogen-rich spirocyclic scaffold featuring a protected amine and a labile Boc group. This configuration enables selective functionalization in late-stage diversification, particularly within medicinal chemistry campaigns requiring constrained heterocyclic frameworks. The oxane linkage enhances solubility while maintaining structural integrity under standard coupling conditions.

Application

2-Boc-5-oxa-2,8-diaza-spiro[3.5]nonan-7-one serves as a versatile, bench-stable building block for the construction of complex nitrogen-containing heterocycles. Its spirocyclic architecture and orthogonal functional groups enable selective transformations in medicinal chemistry workflows, facilitating efficient access to constrained scaffolds via standard deprotection and coupling protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.87
  • LogP   0.1223
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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