tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate

Name: tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate
Brand: ChemScene
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CAS No. 1363380-79-3
Cat. No. CS-0048174
Purity≥97%
MDL No.MFCD22419342

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate|CS-0048174

Structure of 1363380-79-3

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General Information

CAS No. 1363380-79-3
Cat. No. CS-0048174
Purity ≥97%
MDL No. MFCD22419342
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₂N₂O₂
Molecular Weight 226.32
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(CN)C2

Description

tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate features a rigid spirocyclic core with a primary amine handle, enabling direct functionalization in medicinal chemistry. The tert-butyl ester group offers stability and convenient deprotection under mild acidic conditions. This scaffold integrates seamlessly into bioactive molecule design, particularly for constrained peptidomimetics and targeted kinase inhibitors.

Application

tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and process development, enabling efficient access to constrained nitrogen-containing heterocycles. The protected amine and carboxylate functionalities offer orthogonal reactivity, facilitating sequential derivatization. Bench-stable and readily purified by standard chromatography, it functions as a key building block in the synthesis of bioactive molecules via amide coupling, reductive amination, or cyclization strategies.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 55.56
LogP 1.5922
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Amine

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Key Words

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tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate

CAS No. 1363380-79-3

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