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N-(2-Chloropyridin-4-yl)acetamide

  • CAS No. 13602-82-9

  • Cat. No. CS-0084783
  • Molecule weight170.60
  • Purity≥98%
  • MDL No.MFCD00234294

*For research and further manufacturing use only, not for direct human use.

N-(2-Chloropyridin-4-yl)acetamide|CS-0084783

Structure of 13602-82-9

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General Information

  • CAS No. 13602-82-9
  • Cat. No. CS-0084783
  • Purity ≥98%
  • MDL No. MFCD00234294
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O
  • Molecular Weight 170.60
  • Synonym(s) OTAVA-BB BB7017520046
  • SMILES CC(NC1=CC(Cl)=NC=C1)=O

Description

N-(2-Chloropyridin-4-yl)acetamide features a chloropyridine core paired with an acetamide handle, enabling direct integration into transition metal-catalyzed cross-coupling reactions. This bench-stable scaffold delivers efficient access to functionalized pyridine derivatives under standard conditions.

Application

N-(2-Chloropyridin-4-yl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles. Its ortho-chloro group facilitates palladium-catalyzed cross-coupling reactions, while the acetamide functionality offers moderate stability and compatibility with diverse reaction conditions. The molecule functions effectively in late-stage functionalization and scaffold diversification workflows.

Synthesis

  • Route1
    • In-stock
      4-Amino-2-chloropyridine|CS-D1410
      14432-12-3
    • null|null
      75-36-5
    • ~%
    • In-stock
      N-(2-Chloropyridin-4-yl)acetamide|CS-0084783
      13602-82-9

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2556 - 2559

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.99
  • LogP   1.6934
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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