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CS-W001157 4
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5-Oxa-2-azaspiro[3.4]octane hydrochloride

  • CAS No. 1359656-11-3

  • Cat. No. CS-0036013
  • Purity≥97%
  • MDL No.MFCD21364490

*For research and further manufacturing use only, not for direct human use.

5-Oxa-2-azaspiro[3.4]octane hydrochloride|CS-0036013

Structure of 1359656-11-3

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General Information

  • CAS No. 1359656-11-3
  • Cat. No. CS-0036013
  • Purity ≥97%
  • MDL No. MFCD21364490
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂ClNO
  • Molecular Weight 149.62
  • Synonym(s) None
  • SMILES C1CC2(OC1)CNC2.Cl

Description

5-Oxa-2-azaspiro[3.4]octane hydrochloride features a rigid spirocyclic core with embedded oxygen and nitrogen heteroatoms, delivering enhanced metabolic stability and predictable conformational behavior. This scaffold integrates readily into bioactive molecules, enabling efficient access to constrained pharmacophores in medicinal chemistry campaigns.

Application

5-Oxa-2-azaspiro[3.4]octane hydrochloride serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to spirocyclic scaffolds prevalent in bioactive molecules. Its stable, crystalline form facilitates handling and purification, while the constrained spiro architecture supports high stereocontrol in downstream functionalization. The amine functionality enables facile derivatization via alkylation or acylation, and the oxacycle enhances solubility and metabolic stability in lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.5606
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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