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5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine

  • CAS No. 1357945-27-7

  • Cat. No. CS-D1089
  • Molecule weight279.47
  • Purity≥97%
  • MDL No.MFCD16658104

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine|CS-D1089

Structure of 1357945-27-7

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General Information

  • CAS No. 1357945-27-7
  • Cat. No. CS-D1089
  • Purity ≥97%
  • MDL No. MFCD16658104
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClIN₃
  • Molecular Weight 279.47
  • Synonym(s) oro-3-iodo-1H-pyrazoL
  • SMILES IC1=NNC2=CC=C(Cl)N=C21

Description

5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine is a halogenated heterocyclic scaffold featuring complementary reactivity at the 3- and 5-positions. This electron-deficient pyrazolopyridine integrates readily into cross-coupling workflows, enabling rapid access to functionalized N-heterocycles. Bench-stable and moisture-tolerant, it serves as a robust building block for medicinal chemistry and materials synthesis.

Application

5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine serves as a versatile building block for the construction of functionalized pyrazolopyridine scaffolds via palladium-catalyzed cross-coupling reactions. The orthogonal reactivity of the chloro and iodo substituents enables sequential derivatization, facilitating access to diverse heterocyclic architectures. Bench-stable and compatible with standard coupling protocols, it functions as a key intermediate in the synthesis of bioactive molecules and pharmaceutical candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   2.2159
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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