Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Boc-Glu(OBzl)-OH

  • CAS No. 13574-13-5

  • Cat. No. CS-W014497
  • Purity≥95%
  • MDL No.MFCD00065569

*For research and further manufacturing use only, not for direct human use.

Boc-Glu(OBzl)-OH|CS-W014497

Structure of 13574-13-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 13574-13-5
  • Cat. No. CS-W014497
  • Purity ≥95%
  • MDL No. MFCD00065569
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₃NO₆
  • Molecular Weight 337.37
  • Synonym(s) None
  • SMILES O=C(OCC1=CC=CC=C1)CC[C@@H](C(O)=O)NC(OC(C)(C)C)=O

Description

1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.Similar linkers in this series:920533920649920665920703

Synthesis

  • Route1

    References

    • Craighead, Mark; Palin, Ronald; Murray, Neil; Lindsay, Derek Patent: US2013/225594 A1, 2013 ; Location in patent: Paragraph 0425; 0426 ;
  • Route2
    • null|null
      132090-12-1
    • ~50%
    • In-stock
      Boc-Glu(OBzl)-OH|CS-W014497
      13574-13-5

    References

    • Fotakopoulou, Irene; Barbayianni, Efrosini; Constantinou-Kokotou, Violetta; Bornscheuer, Uwe T.; Kokotos, George Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 782 - 786
  • Route3
    • null|null
      13574-84-0
    • ~92%
    • In-stock
      Boc-Glu(OBzl)-OH|CS-W014497
      13574-13-5

    References

    • Onoprienko; Yelin; Miroshnikov Russian Journal of Bioorganic Chemistry, 2000 , vol. 26, # 6 p. 361 - 368

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   101.93
  • LogP   2.4879
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   7

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Boc-Glu(OBzl)-OH sigmaBoc-Glu(OBzl)-OH manufacturerBoc-Glu(OBzl)-OH priceBoc-Glu(OBzl)-OH structureBoc-Glu(OBzl)-OH SDSbuy Boc-Glu(OBzl)-OHBoc-Glu(OBzl)-OH supplierBoc-Glu(OBzl)-OH usesBoc-Glu(OBzl)-OH molecular weightprice of Boc-Glu(OBzl)-OHBoc-Glu(OBzl)-OH chemical name formula of Boc-Glu(OBzl)-OH
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label