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CS-W001157 4
Total: USD 88.00

4-Bromo-5-fluoro-2-methylbenzoic acid

  • CAS No. 1349715-55-4

  • Cat. No. CS-W022109
  • Purity≥98%
  • MDL No.MFCD18917157

*For research and further manufacturing use only, not for direct human use.

4-Bromo-5-fluoro-2-methylbenzoic acid|CS-W022109

Structure of 1349715-55-4

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General Information

  • CAS No. 1349715-55-4
  • Cat. No. CS-W022109
  • Purity ≥98%
  • MDL No. MFCD18917157
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO₂
  • Molecular Weight 233.03
  • Synonym(s) None
  • SMILES O=C(O)C1=CC(F)=C(Br)C=C1C

Description

4-Bromo-5-fluoro-2-methylbenzoic acid features a trifunctional aromatic core with bromine, fluorine, and methyl groups positioned for orthogonal reactivity. The carboxylic acid moiety enables direct coupling in cross-coupling or amide formation protocols. This electron-deficient aryl scaffold offers enhanced stability under standard conditions and compatibility with transition metal catalysis.

Application

4-Bromo-5-fluoro-2-methylbenzoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methyl group enables directed functionalization, while the bromo and fluoro substituents support palladium-catalyzed cross-coupling reactions. The carboxylic acid functionality facilitates derivatization via amide or ester formation, offering excellent stability and ease of purification in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.59482
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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