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Thiol-PEG3-acid

  • CAS No. 1347750-82-6

  • Cat. No. CS-0114525
  • Molecule weight238.30
  • Purity≥95%
  • MDL No.MFCD25424073

*For research and further manufacturing use only, not for direct human use.

Thiol-PEG3-acid|CS-0114525

Structure of 1347750-82-6

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General Information

  • CAS No. 1347750-82-6
  • Cat. No. CS-0114525
  • Purity ≥95%
  • MDL No. MFCD25424073
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈O₅S
  • Molecular Weight 238.30
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCS

Description

Thiol-PEG3-acid features a terminal thiol group conjugated to a three-ethylene glycol spacer terminating in a carboxylic acid. This bifunctional architecture enables site-specific bioconjugation via thiol-maleimide or thiol-ene reactions, while the acid moiety facilitates coupling to amine-containing biomolecules. The PEG3 spacer provides enhanced solubility and reduced non-specific binding, making this reagent ideal for protein labeling, probe synthesis, and drug delivery applications.

Application

Thiol-PEG3-acid serves as a versatile bifunctional linker for conjugation chemistries, combining a reactive thiol group with a terminal carboxylic acid. The PEG3 spacer provides enhanced solubility and reduced aggregation, while the thiol enables site-specific coupling to maleimides or gold surfaces, and the acid facilitates amide bond formation with amines under standard activation conditions. This structure offers excellent bench stability, clean purification profiles, and broad compatibility in peptide, antibody-drug conjugate, and nanoparticle functionalization workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.99
  • LogP   0.4407
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   11

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