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CS-W001157 4
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1-Ethyl-3-hydroxypiperidine

  • CAS No. 13444-24-1

  • Cat. No. CS-0075008
  • Molecule weight129.20
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Ethyl-3-hydroxypiperidine|CS-0075008

Structure of 13444-24-1

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General Information

  • CAS No. 13444-24-1
  • Cat. No. CS-0075008
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) N-ethyl-3-piperidinol
  • SMILES OC1CN(CC)CCC1

Description

1-Ethyl-3-hydroxypiperidine is a sterically accessible piperidine derivative featuring a hydroxyl group at the 3-position and an ethyl substituent at nitrogen. This configuration enables efficient incorporation into medicinal chemistry scaffolds, where the hydroxyl moiety offers a handle for derivatization. The molecule exhibits favorable solubility and stability under standard bench conditions, facilitating its use in synthetic workflows requiring polar, nitrogen-containing heterocycles.

Application

1-Ethyl-3-hydroxypiperidine serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The hydroxyl group provides a handle for selective derivatization, while the ethyl substituent enhances metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with standard coupling and protection protocols facilitate straightforward incorporation into complex molecules.

Synthesis

  • Route1
    • 1-Ethylpiperidin-3-one|CS-0965092
      43152-93-8
    • ~%
    • In-stock
      1-Ethyl-3-hydroxypiperidine|CS-0075008
      13444-24-1

    References

    • Journal of the American Chemical Society, , vol. 71, p. 2041
  • Route2
    • 1-ethyl-3-hydroxy-Pyridinium bromide 1:1|CS-0279186
      80866-84-8
    • ~%
    • In-stock
      1-Ethyl-3-hydroxypiperidine|CS-0075008
      13444-24-1

    References

    • Journal of the American Chemical Society, , vol. 81, p. 5140,5145
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 5140,5145

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   0.463
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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