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CS-W001157 4
Total: USD 88.00

N-(Trimethylsilyl)acetamide

  • CAS No. 13435-12-6

  • Cat. No. CS-0187550
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-(Trimethylsilyl)acetamide|CS-0187550

Structure of 13435-12-6

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General Information

  • CAS No. 13435-12-6
  • Cat. No. CS-0187550
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₃NOSi
  • Molecular Weight 131.25
  • Synonym(s) N-TMS-acetamide; N-(Trimethylsilyl)acetamide
  • SMILES CC(N[Si](C)(C)C)=O

Description

N-(Trimethylsilyl)acetamide serves as a stable, moisture-tolerant silylating agent for hydroxyl and amine functionalities. This bench-stable reagent facilitates selective protection under mild conditions, enabling efficient derivatization in synthetic organic chemistry workflows.

Synthesis

  • Route1
    • In-stock
      Acetamide|CS-0015934
      60-35-5
    • null|null
      999-97-3
    • ~84%
    • In-stock
      N-(Trimethylsilyl)acetamide|CS-0187550
      13435-12-6

    References

    • Bruynes, Cornelis A.; Jurriens, Theodorus K. Journal of Organic Chemistry, 1982 , vol. 47, # 20 p. 3966 - 3969
  • Route2
    • null|null
      146558-05-6
    • null|null
      410076-93-6
    • ~%
    • In-stock
      N-(Trimethylsilyl)acetamide|CS-0187550
      13435-12-6
    • null|null
      410076-97-0

    References

    • Soerensen, Mads D.; Kvaernoe, Lisbet; Bryld, Torsten; Hakansson, Anders E.; Verbeure, Birgit; Gaubert, Gilles; Herdewijn, Piet; Wengel, Jesper Journal of the American Chemical Society, 2002 , vol. 124, # 10 p. 2164 - 2176
  • Route3
    • null|null
      563-80-4
    • null|null
      10416-59-8
    • ~0%
    • null|null
      17510-45-1
    • In-stock
      N-(Trimethylsilyl)acetamide|CS-0187550
      13435-12-6

    References

    • Dedier, James; Gerval, Pierre; Frainnet, Emile Journal of Organometallic Chemistry, 1980 , vol. 185, # 2 p. 183 - 198

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.9574
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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