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CS-W001157 4
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Diethyl aminomalonate hydrochloride

  • CAS No. 13433-00-6

  • Cat. No. CS-W019859
  • Purity≥95%
  • MDL No.MFCD00012510

*For research and further manufacturing use only, not for direct human use.

Diethyl aminomalonate hydrochloride|CS-W019859

Structure of 13433-00-6

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General Information

  • CAS No. 13433-00-6
  • Cat. No. CS-W019859
  • Purity ≥95%
  • MDL No. MFCD00012510
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClNO₄
  • Molecular Weight 211.64
  • Synonym(s) Propanedioic acid, amino-, diethyl ester, hydrochloride
  • SMILES O=C(OCC)C(N)C(OCC)=O.Cl

Description

Diethyl aminomalonate hydrochloride serves as a stabilized, bench-ready synthon for C–C bond formation. The protonated amine enhances solubility and reactivity in polar media, enabling efficient enolate generation under mild conditions. This derivative integrates seamlessly into multistep sequences requiring nitrogen-tethered malonate equivalents, delivering high functional group tolerance and predictable regiochemistry in asymmetric synthesis workflows.

Application

Diethyl aminomalonate hydrochloride serves as a versatile building block in synthetic organic chemistry, enabling the efficient construction of β-amino carbonyl compounds and heterocyclic scaffolds. Its stabilized enolizable α-position facilitates nucleophilic additions and condensation reactions, while the protonated amine enhances solubility and handling. The salt form improves bench stability and simplifies purification, making it well-suited for multi-step syntheses and scale-up applications.

Synthesis

  • Route1
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      64-17-5
    • ~%
    • In-stock
      Diethyl aminomalonate hydrochloride|CS-W019859
      13433-00-6

    References

    • Chemische Berichte, , vol. 39, p. 514

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   78.62
  • LogP   -0.1383
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   4

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