Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3,4,5-Trifluorobenzonitrile

  • CAS No. 134227-45-5

  • Cat. No. CS-W019259
  • Purity≥98%
  • MDL No.MFCD00074948

*For research and further manufacturing use only, not for direct human use.

3,4,5-Trifluorobenzonitrile|CS-W019259

Structure of 134227-45-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 134227-45-5
  • Cat. No. CS-W019259
  • Purity ≥98%
  • MDL No. MFCD00074948
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₂F₃N
  • Molecular Weight 157.09
  • Synonym(s) Benzonitrile, 3,4,5-trifluoro-
  • SMILES C1=C(C=C(F)C(=C1F)F)C#N

Description

3,4,5-Trifluorobenzonitrile delivers a trifluorinated aromatic core with a nitrile group positioned for strategic functionalization. This electron-deficient scaffold enables direct coupling reactions and serves as a key building block in pharmaceutical synthesis. The fluorine substituents enhance metabolic stability and modulate electronic properties. Its bench-stable nature simplifies handling under standard conditions.

Application

3,4,5-Trifluorobenzonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling direct functionalization at the aromatic ring due to its strong electron-withdrawing trifluoromethyl group. The nitrile functionality facilitates nucleophilic addition, amide formation, and transition-metal-catalyzed coupling reactions. Its high bench stability and compatibility with diverse reaction conditions make it ideal for constructing fluorinated heterocycles and pharmaceutical scaffolds.

Synthesis

  • Route1

    References

    • EP2151432 A1, ; Page/Page column 53 ;
  • Route2
    • null|null
      544-92-3
    • In-stock
      1-Bromo-3,4,5-trifluorobenzene|CS-W015081
      138526-69-9
    • ~%
    • In-stock
      3,4,5-Trifluorobenzonitrile|CS-W019259
      134227-45-5

    References

    • WO2007/49728 A1, ; Page/Page column 162-163 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3439
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H312-H315-H319-H331-H335
Precautionary Statements : P261-P280-P304+P340

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   23.79
  • LogP   1.97558
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3,4,5-Trifluorobenzonitrile sigma3,4,5-Trifluorobenzonitrile manufacturer3,4,5-Trifluorobenzonitrile price3,4,5-Trifluorobenzonitrile structure3,4,5-Trifluorobenzonitrile SDSbuy 3,4,5-Trifluorobenzonitrile3,4,5-Trifluorobenzonitrile supplier3,4,5-Trifluorobenzonitrile uses3,4,5-Trifluorobenzonitrile molecular weightprice of 3,4,5-Trifluorobenzonitrile3,4,5-Trifluorobenzonitrile chemical name formula of 3,4,5-Trifluorobenzonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label