2-AMINO-5-METHOXYPYRIMIDINE

Name: 2-AMINO-5-METHOXYPYRIMIDINE
Brand: ChemScene
Availability: InStock
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CAS No. 13418-77-4
Cat. No. CS-W000479
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 13418-77-4

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General Information

CAS No. 13418-77-4
Cat. No. CS-W000479
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₇N₃O
Molecular Weight 125.13
Synonym(s) 5-Methoxy-2-pyrimidinamine; 2-Amino-5-methoxypyrimidine
SMILES COc1cnc(N)nc1

Description

2-Amino-5-methoxypyrimidine is a bench-stable heterocyclic building block featuring an amino group at C2 and a methoxy substituent at C5, enabling efficient incorporation into pharmaceutical intermediates. The electron-rich pyrimidine core facilitates transition metal-catalyzed coupling reactions, while the methoxy group enhances solubility and modulates reactivity in synthetic sequences.

Application

2-Amino-5-methoxypyrimidine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds through standard coupling and functionalization reactions. Its amino and methoxy groups offer orthogonal reactivity for sequential derivatization, while its bench-stable nature facilitates handling and purification in multi-step syntheses.

Synthesis

Route1
- 506-93-4
- 68-12-2
- 24332-20-5
- ~51%
- In-stock
  
  13418-77-4
References
- VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie Patent: WO2013/171281 A1, 2013 ; Location in patent: Page/Page column 109-110 ;
Route2
- In-stock
  
  22536-65-8
- ~54%
- In-stock
  
  13418-77-4
References
- ACADIA PHARMACEUTICALS INC. Patent: WO2008/141239 A1, 2008 ; Location in patent: Page/Page column 54 ; WO 2008/141239 A1
Route3
- In-stock
  
  651-06-9
- ~%
- 16290-93-0
- 63-74-1
- In-stock
  
  13418-77-4
- 121-57-3
References
- Die Pharmazie, , vol. 42, # 8 p. 511 - 513

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 61.03
LogP 0.0674
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-AMINO-5-METHOXYPYRIMIDINE

CAS No. 13418-77-4

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