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CS-W001157 4
Total: USD 88.00

TBDMS-PEG4-OH

  • CAS No. 134179-40-1

  • Cat. No. CS-0035582
  • Purity≥95%
  • MDL No.MFCD25424114

*For research and further manufacturing use only, not for direct human use.

TBDMS-PEG4-OH|CS-0035582

Structure of 134179-40-1

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General Information

  • CAS No. 134179-40-1
  • Cat. No. CS-0035582
  • Purity ≥95%
  • MDL No. MFCD25424114
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₃₂O₅Si
  • Molecular Weight 308.49
  • Synonym(s) None
  • SMILES CC(C)([Si](C)(OCCOCCOCCOCCO)C)C

Description

TBDMS-PEG4-OH features a tert-butyldimethylsilyl-protected hydroxyl group at one end and a terminal hydroxyl at the other, enabling orthogonal functionalization. This bifunctional PEG derivative offers enhanced solubility in organic solvents while maintaining stability under standard handling conditions.

Application

TBDMS-PEG4-OH serves as a versatile, bench-stable bifunctional building block for the synthesis of PEGylated compounds and protected oligoether linkages. The tert-butyldimethylsilyl (TBDMS) group provides reliable protection for hydroxyl functionalities during multistep syntheses, while the terminal primary alcohol enables conjugation via standard coupling reactions. Its PEG4 spacer offers enhanced solubility and reduced aggregation in aqueous environments, making it ideal for applications in medicinal chemistry, bioconjugation, and polymer-linked reagent design.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   57.15
  • LogP   2.0503
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   12

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