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CS-W001157 4
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7-Amino-2,3-dihydrobenzofuran

  • CAS No. 13414-56-7

  • Cat. No. CS-B1184
  • Purity≥98%
  • MDL No.MFCD11109313

*For research and further manufacturing use only, not for direct human use.

7-Amino-2,3-dihydrobenzofuran|CS-B1184

Structure of 13414-56-7

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General Information

  • CAS No. 13414-56-7
  • Cat. No. CS-B1184
  • Purity ≥98%
  • MDL No. MFCD11109313
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO
  • Molecular Weight 135.16
  • Synonym(s) (2,3-Dihydrobenzofuran-7-yl)amine; 2,3-Dihydro-7-benzofuranamine; 7-Benzofuranamine, 2,3-dihydro-
  • SMILES NC1=C(OCC2)C2=CC=C1

Description

7-Amino-2,3-dihydrobenzofuran is a heterocyclic scaffold featuring a fused benzene and tetrahydrofuran ring system with a primary amine at the 7-position. This electron-rich moiety serves as a key building block in medicinal chemistry, enabling direct incorporation into bioactive molecules through nucleophilic coupling reactions. The compound exhibits favorable solubility and stability under standard bench conditions, facilitating its use in synthetic workflows targeting CNS agents and kinase inhibitors.

Application

7-Amino-2,3-dihydrobenzofuran serves as a versatile building block in medicinal chemistry, enabling direct access to bioactive heterocycles through standard functionalization. Its electron-rich aromatic core and amine functionality facilitate coupling reactions, electrophilic substitutions, and derivatization under mild conditions. Bench-stable and readily purified, it functions effectively in the synthesis of pharmaceutical intermediates and targeted scaffolds.

Synthesis

  • Route1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 24 p. 5567 - 5573
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 24 p. 5567 - 5573

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.2037
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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