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CS-W001157 4
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5-(Bromomethyl)thiophene-2-carbonitrile

  • CAS No. 134135-41-4

  • Cat. No. CS-W022255
  • Purity≥98%
  • MDL No.MFCD08236857
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

5-(Bromomethyl)thiophene-2-carbonitrile|CS-W022255

Structure of 134135-41-4

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Description

5-(Bromomethyl)thiophene-2-carbonitrile features a bromomethyl group flanked by a thiophene ring and a nitrile moiety, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. This bench-stable derivative integrates readily into complex molecular architectures requiring orthogonal reactivity.

Application

5-(Bromomethyl)thiophene-2-carbonitrile serves as a versatile building block for the synthesis of functionalized thiophene derivatives. The bromomethyl group enables efficient nucleophilic substitution and cross-coupling reactions, while the pendant nitrile functions as a handle for further transformation into carboxylic acids, amides, or heterocycles. Its bench-stable nature and compatibility with standard synthetic protocols make it ideal for medicinal chemistry and materials science applications.

General Information

  • CAS No. 134135-41-4
  • Cat. No. CS-W022255
  • Purity ≥98%
  • MDL No. MFCD08236857
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrNS
  • Molecular Weight 202.07
  • Synonym(s) 5-(Bromomethyl)-2-thiophenecarbonitrile
  • SMILES BrCC1=CC=C(S1)C#N

Computational Chemistry Data

  • TPSA   23.79
  • LogP   2.51468
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P363-P405-P501

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