(1S)-1-Cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride

Name: (1S)-1-Cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 1338377-73-3
Cat. No. CS-0053588
Purity≥97%
MDL No.MFCD26569801

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(1S)-1-Cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride|CS-0053588

Structure of 1338377-73-3

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General Information

CAS No. 1338377-73-3
Cat. No. CS-0053588
Purity ≥97%
MDL No. MFCD26569801
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₉ClF₃N
Molecular Weight 175.58
Synonym(s) (1S)-1-cyclopropyl-2,2,2-trifluoroethylamine hydrochloride
SMILES Cl.N[C@@H](C1CC1)C(F)(F)F

Description

(1S)-1-Cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride delivers a chiral trifluoromethylated amine scaffold with enhanced metabolic stability. The cyclopropyl group imparts conformational rigidity, while the trifluoroethanol moiety provides strong electron-withdrawing character. This bench-stable salt facilitates direct incorporation into bioactive molecules and supports efficient synthetic access to fluorinated pharmaceutical intermediates under standard conditions.

Application

(1S)-1-Cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride serves as a stereochemically defined building block for fluorinated bioactive molecules. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the cyclopropyl moiety imparts conformational rigidity. The amine functionality enables straightforward derivatization via amidation, alkylation, or reductive amination, facilitating rapid access to diverse scaffolds in medicinal chemistry campaigns. Bench-stable and readily purified by standard methods, it supports scalable synthesis of target compounds with predictable stereochemical fidelity.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 26.02
LogP 1.7078
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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(1S)-1-Cyclopropyl-2,2,2-trifluoroethan-1-amine hydrochloride

CAS No. 1338377-73-3

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