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CS-W001157 4
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tert-Butyl 6-hydroxy-1H-indazole-1-carboxylate

  • CAS No. 1337880-58-6

  • Cat. No. CS-0041750
  • Molecule weight234.25
  • Purity≥97%
  • MDL No.MFCD22380235

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 6-hydroxy-1H-indazole-1-carboxylate|CS-0041750

Structure of 1337880-58-6

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General Information

  • CAS No. 1337880-58-6
  • Cat. No. CS-0041750
  • Purity ≥97%
  • MDL No. MFCD22380235
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄N₂O₃
  • Molecular Weight 234.25
  • Synonym(s) None
  • SMILES O=C(N1N=CC2=C1C=C(O)C=C2)OC(C)(C)C

Description

tert-Butyl 6-hydroxy-1H-indazole-1-carboxylate features a bench-stable indazole core with a strategically positioned hydroxyl group enabling downstream functionalization. The tert-butyl ester facilitates purification and protection of the carboxylic acid, while the electron-rich heterocycle supports transition metal-catalyzed coupling reactions. This compound serves as a key intermediate in the synthesis of bioactive indazole derivatives.

Application

tert-Butyl 6-hydroxy-1H-indazole-1-carboxylate serves as a versatile building block for indazole-based scaffolds, enabling straightforward functionalization at the C6 position. The hydroxyl group facilitates derivatization via esterification, etherification, or transition-metal-catalyzed coupling reactions. Its tert-butyl carbamate handle provides stability and ease of removal under mild acidic conditions, supporting efficient synthesis of biologically relevant indazole derivatives in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.35
  • LogP   2.5251
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   0

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