Fmoc-NH-PEG8-NHS ester

Name: Fmoc-NH-PEG8-NHS ester
Brand: ChemScene
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CAS No. 1334170-03-4
Cat. No. CS-0107973
Purity≥95%
MDL No.MFCD21363318

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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General Information

CAS No. 1334170-03-4
Cat. No. CS-0107973
Purity ≥95%
MDL No. MFCD21363318
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₈H₅₂N₂O₁₄
Molecular Weight 760.82
Synonym(s) None
SMILES O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON4C(CCC4=O)=O)=O

Description

Fmoc-NH-PEG8-NHS ester enables efficient conjugation in peptide and biomolecule synthesis. This water-soluble linker features a reactive NHS ester for amine coupling, a central PEG8 spacer for enhanced solubility, and an Fmoc group for orthogonal protection. Designed for robust, site-specific labeling under standard conditions.

Application

Fmoc-NH-PEG8-NHS ester serves as a versatile bifunctional linker for peptide and protein conjugation. The Fmoc group enables orthogonal protection during solid-phase synthesis, while the NHS ester readily reacts with primary amines under physiological conditions. The eight-ethylene glycol unit provides enhanced solubility and stability in aqueous environments, minimizing non-specific binding. This reagent facilitates efficient conjugation workflows in bioconjugate chemistry, offering reliable purification and consistent yields in antibody-drug conjugate and peptide-protein fusion applications.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 175.85
LogP 2.6552
H_Acceptors 14
H_Donors 1
Rotatable_Bonds 30

Other Classifications

Life Science Crosslinking Agent

Life Science Linker Fmoc PEG

Life Science Linker PEG NHS ester

Building Blocks Functional Group PEG

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Key Words

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Fmoc-NH-PEG8-NHS ester

CAS No. 1334170-03-4

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