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CS-W001157 4
Total: USD 88.00

6-Iodoquinoline

  • CAS No. 13327-31-6

  • Cat. No. CS-W003518
  • Purity≥95%
  • MDL No.MFCD08457906

*For research and further manufacturing use only, not for direct human use.

6-Iodoquinoline|CS-W003518

Structure of 13327-31-6

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General Information

  • CAS No. 13327-31-6
  • Cat. No. CS-W003518
  • Purity ≥95%
  • MDL No. MFCD08457906
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆IN
  • Molecular Weight 255.06
  • Synonym(s) 6-iodo-Quinoline
  • SMILES Ic1ccc2c(c1)cccn2

Application

6-Iodoquinoline serves as a versatile building block in medicinal chemistry and cross-coupling strategies. The iodine substituent enables reliable palladium-catalyzed transformations, including Suzuki, Stille, and Negishi couplings, facilitating the construction of biaryl and heteroaryl architectures. Its stability under standard reaction conditions and compatibility with diverse functional groups make it a practical choice for synthesizing complex quinoline-based scaffolds in drug discovery and materials science.

Synthesis

  • Route1

    References

    • Cheng, Yuan; Judd, Ted C.; Bartberger, Michael D.; Brown, James; Chen, Kui; Fremeau Jr., Robert T.; Hickman, Dean; Hitchcock, Stephen A.; Jordan, Brad; Li, Vivian; Lopez, Patricia; Louie, Steven W.; Luo, Yi; Michelsen, Klaus; Nixey, Thomas; Powers, Timothy S.; Rattan, Claire; Sickmier, E. Allen; St. Jean Jr., David J.; Wahl, Robert C.; Wen, Paul H.; Wood, Stephen Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5836 - 5857

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8394
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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