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Structure of 133232-56-1
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3-Iodo-2-methylbenzoic acid features a sterically hindered ortho-iodo substituent flanking a methyl group and carboxylic acid moiety, enabling direct functionalization in late-stage diversification. This bench-stable derivative integrates readily into cross-coupling protocols, delivering access to complex aromatic scaffolds with minimal purification overhead.
3-Iodo-2-methylbenzoic acid serves as a versatile building block for the synthesis of functionalized aromatic scaffolds, particularly in Suzuki-Miyaura and Stille coupling reactions. Its ortho-methyl group enhances regioselectivity in electrophilic substitutions, while the carboxylic acid facilitates derivatization via amide or ester formation. The iodine substituent provides high reactivity in cross-coupling protocols, enabling efficient access to biaryl architectures. Bench-stable and readily purified by recrystallization, it functions as a reliable intermediate in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: