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CS-W001157 4
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N,N-Dimethyl-1H-pyrazole-1-sulfonamide

  • CAS No. 133228-21-4

  • Cat. No. CS-0113943
  • Purity≥98%
  • MDL No.MFCD11865226

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethyl-1H-pyrazole-1-sulfonamide|CS-0113943

Structure of 133228-21-4

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General Information

  • CAS No. 133228-21-4
  • Cat. No. CS-0113943
  • Purity ≥98%
  • MDL No. MFCD11865226
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉N₃O₂S
  • Molecular Weight 175.21
  • Synonym(s) 1-(N,N-diMethyl-sulfaMoyl)pyrazole
  • SMILES O=S(N1N=CC=C1)(N(C)C)=O

Description

N,N-Dimethyl-1H-pyrazole-1-sulfonamide features a pyrazole core bearing a sulfonamide group and two methyl substituents, delivering enhanced solubility and metabolic stability. This scaffold integrates readily into medicinal chemistry libraries, offering a polar yet lipophilic moiety for probing target engagement in kinase and enzyme inhibition studies.

Application

N,N-Dimethyl-1H-pyrazole-1-sulfonamide serves as a versatile sulfonamide building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through established coupling and functionalization protocols. Its dimethylamino group enhances solubility and provides a handle for further derivatization, while the pyrazole core offers robust stability and orthogonal reactivity. The compound exhibits favorable bench stability and ease of purification, making it well-suited for iterative synthesis campaigns in API development and target-oriented discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.2
  • LogP   -0.4624
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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