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tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate

  • CAS No. 1331825-50-3

  • Cat. No. CS-0048292
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate|CS-0048292

Structure of 1331825-50-3

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General Information

  • CAS No. 1331825-50-3
  • Cat. No. CS-0048292
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₁NO₄
  • Molecular Weight 243.30
  • Synonym(s) 7-Boc-3-hydroxy-1-oxa-7-azaspiro[4.4]nonane - H11623
  • SMILES CC(C)(C)OC(=O)N1CCC2(CC(O)CO2)C1

Description

tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate features a spirocyclic scaffold integrating a hydroxyl group and a protected carboxylic acid, enabling direct functionalization in complex molecule synthesis. The tert-butyl ester ensures excellent stability and ease of manipulation under standard conditions.

Application

tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry and natural product synthesis. The molecule features a stable spirocyclic core with orthogonal functional groups: a tertiary alcohol for selective derivatization and a tert-butyl ester enabling mild deprotection. Its rigidity enhances conformational control in target molecules, while the hydroxyl group facilitates glycosylation, etherification, or oxidation reactions. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it ideal for high-throughput library construction and process-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59
  • LogP   1.1472
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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