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Structure of 13280-07-4
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4-Chlorobut-2-yn-1-ol features a terminal alkyne group flanked by a chlorinated carbon and a hydroxyl-bearing carbon, enabling direct conjugation in click chemistry and transition-metal-catalyzed coupling reactions. This moisture-tolerant reagent integrates readily into molecular scaffolds requiring precise functionalization under mild conditions.
4-Chlorobut-2-yn-1-ol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized alkynes and heterocyclic scaffolds. Its terminal alkyne functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the primary alcohol supports selective derivatization and protection strategies. The molecule exhibits good bench stability and compatibility with standard reaction conditions, making it well-suited for use in medicinal chemistry campaigns and process-scale synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H302-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: