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CS-W001157 4
Total: USD 88.00

Fmoc-Asn(Trt)-OH

  • CAS No. 132388-59-1

  • Cat. No. CS-W002327
  • Purity≥98%
  • MDL No.MFCD00077049

*For research and further manufacturing use only, not for direct human use.

Fmoc-Asn(Trt)-OH|CS-W002327

Structure of 132388-59-1

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General Information

  • CAS No. 132388-59-1
  • Cat. No. CS-W002327
  • Purity ≥98%
  • MDL No. MFCD00077049
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₈H₃₂N₂O₅
  • Molecular Weight 596.67
  • Synonym(s) None
  • SMILES O=C(NC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C[C@@H](C(O)=O)NC(OCC4C5=C(C=CC=C5)C6=C4C=CC=C6)=O

Description

Fmoc-Asn(Trt)-OH has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Asn [1, 2]. Coupling can be performed by standard procedures. The trityl group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp residues. When Asn(Trt) is the N-terminal residue, the reaction time may need to be extended to ensure complete deprotection [3].Fmoc-Asn(Trt)-OH has been used to synthesize peptides on cellulose membrane by SPOT method

Synthesis

  • Route1
    • Triphenylmethanol Fimasartan Impurity|CS-0228989
      76-84-6
    • In-stock
      Fmoc-Asn-OH|CS-W009801
      71989-16-7
    • null|null
      107-06-2
    • ~%
    • In-stock
      Fmoc-Asn(Trt)-OH|CS-W002327
      132388-59-1

    References

    • US5324833 A1, ;
  • Route2
    • Triphenylmethanol Fimasartan Impurity|CS-0228989
      76-84-6
    • ~%
    • In-stock
      Fmoc-Asn(Trt)-OH|CS-W002327
      132388-59-1

    References

    • Tetrahedron Letters, , vol. 32, # 6 p. 739 - 742
  • Route3

    References

    • Tetrahedron Letters, , vol. 32, # 6 p. 739 - 742

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H411
Precautionary Statements : P273-P391-P501

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Computational Chemistry Data

  • TPSA   104.73
  • LogP   6.4767
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   10

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