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CS-W001157 4
Total: USD 88.00

2,4-Dihydroxybenzhydrazide

  • CAS No. 13221-86-8

  • Cat. No. CS-0204866
  • Purity≥97%
  • MDL No.MFCD00017053

*For research and further manufacturing use only, not for direct human use.

2,4-Dihydroxybenzhydrazide|CS-0204866

Structure of 13221-86-8

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General Information

  • CAS No. 13221-86-8
  • Cat. No. CS-0204866
  • Purity ≥97%
  • MDL No. MFCD00017053
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₃
  • Molecular Weight 168.15
  • Synonym(s) 2,4-Dihydroxybenzoylhydrazine
  • SMILES O=C(NN)C1=CC=C(O)C=C1O

Application

2,4-Dihydroxybenzhydrazide serves as a versatile scaffold for constructing heterocyclic systems, particularly in the synthesis of pyridazines and quinazolines. Its dual hydroxyl groups enable facile derivatization and metal chelation, while the hydrazide functionality facilitates condensation reactions with carbonyl compounds under mild conditions. The compound exhibits good bench stability and is compatible with common purification techniques, making it a practical building block for medicinal chemistry campaigns involving nitrogen-rich heterocycles.

Synthesis

  • Route1

    References

    • Tetrahedron, , vol. 63, # 50 p. 12437 - 12445
  • Route2
    • Ethyl 2,4-dihydroxybenzoate|CS-0514803
      4143-00-4
    • ~69%
    • In-stock
      2,4-Dihydroxybenzhydrazide|CS-0204866
      13221-86-8

    References

    • European Journal of Medicinal Chemistry, , vol. 47, # 1 p. 452 - 461
  • Route3
    • 2,4-Dihydroxybenzoic acid Sodium aminosalicylate  Impurity|CS-0228943
      89-86-1
    • ~%
    • In-stock
      2,4-Dihydroxybenzhydrazide|CS-0204866
      13221-86-8

    References

    • Bioorganic and Medicinal Chemistry, , vol. 4, # 9 p. 1421 - 1427

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   95.58
  • LogP   -0.2987
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   1

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