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CS-W001157 4
Total: USD 88.00

1-(3-Hydroxypyridin-2-yl)ethanone

  • CAS No. 13210-29-2

  • Cat. No. CS-W019613
  • Molecule weight137.14
  • Purity≥98%
  • MDL No.MFCD08062669

*For research and further manufacturing use only, not for direct human use.

1-(3-Hydroxypyridin-2-yl)ethanone|CS-W019613

Structure of 13210-29-2

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General Information

  • CAS No. 13210-29-2
  • Cat. No. CS-W019613
  • Purity ≥98%
  • MDL No. MFCD08062669
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) Ethanone, 1-(3-hydroxy-2-pyridinyl)- (9CI)
  • SMILES CC(C1=NC=CC=C1O)=O

Description

1-(3-Hydroxypyridin-2-yl)ethanone features a pyridinone scaffold with a pendant ketone, enabling direct integration into heterocyclic synthesis. The hydroxyl group supports hydrogen bonding and enhances solubility in polar solvents, while the carbonyl facilitates nucleophilic addition and condensation reactions under standard conditions. This compound serves as a key intermediate for bioactive molecule construction.

Application

1-(3-Hydroxypyridin-2-yl)ethanone serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridine-based scaffolds through standard functional group transformations. Its hydroxypyridine moiety provides orthogonal reactivity for derivatization, while the acetyl group facilitates electrophilic substitution and condensation reactions. The compound exhibits good bench stability and compatibility with common purification techniques, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      75-16-1
    • In-stock
      3-Hydroxypicolinonitrile|CS-W011210
      932-35-4
    • ~99%
    • In-stock
      1-(3-Hydroxypyridin-2-yl)ethanone|CS-W019613
      13210-29-2

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2123652 A1, 2009 ; Location in patent: Page/Page column 63 ;
  • Route2
    • In-stock
      3-Hydroxypicolinic acid, matrix substance for MALDI-MS|CS-0899663
      874-24-8
    • null|null
      676-58-4
    • ~75%
    • In-stock
      1-(3-Hydroxypyridin-2-yl)ethanone|CS-W019613
      13210-29-2

    References

    • SMITHKLINE BEECHAM CORPORATION Patent: US2008/262224 A1, 2008 ; Location in patent: Page/Page column 14-15 ;
  • Route3
    • null|null
      917-64-6
    • null|null
      63668-59-7
    • ~66%
    • In-stock
      1-(3-Hydroxypyridin-2-yl)ethanone|CS-W019613
      13210-29-2

    References

    • AMGEN INC. Patent: WO2009/126584 A1, 2009 ; Location in patent: Page/Page column 62-63 ; WO 2009/126584 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.9898
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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