tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate

Name: tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate
Brand: ChemScene
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CAS No. 1319716-41-0
Cat. No. CS-0048137
Purity≥95%
MDL No.None

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tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate|CS-0048137

Structure of 1319716-41-0

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General Information

CAS No. 1319716-41-0
Cat. No. CS-0048137
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₂₃NO₃
Molecular Weight 241.33
Synonym(s) 7-Hydroxy-2-aza-spiro[4.4]nonane-2-carboxylic acid tert-butyl ester
SMILES O=C(N1CC2(CC(O)CC2)CC1)OC(C)(C)C

Description

tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate features a rigid spirocyclic scaffold with a hydroxyl group at the 7-position and a tert-butyloxycarbonyl-protected amine at the 2-position. This configuration enables direct functionalization at the hydroxyl site while maintaining stability under standard conditions, facilitating efficient access to complex nitrogen-containing architectures in medicinal chemistry and natural product synthesis.

Application

tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate serves as a versatile spirocyclic scaffold for medicinal chemistry applications, offering a rigid, three-dimensional core with orthogonal functional handles. The hydroxyl group enables direct derivatization via esterification or oxidation to ketone, while the tert-butyl carbamate protects the secondary amine under standard reaction conditions. Its bench-stable nature and compatibility with diverse coupling and cyclization protocols facilitate efficient access to complex heterocyclic architectures in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

TPSA 49.77
LogP 2.1584
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Boc

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Key Words

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tert-Butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate

CAS No. 1319716-41-0

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