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CS-W001157 4
Total: USD 88.00

Benzofuran-5-ol

  • CAS No. 13196-10-6

  • Cat. No. CS-W004630
  • Purity≥98%
  • MDL No.MFCD10699412

*For research and further manufacturing use only, not for direct human use.

Benzofuran-5-ol|CS-W004630

Structure of 13196-10-6

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General Information

  • CAS No. 13196-10-6
  • Cat. No. CS-W004630
  • Purity ≥98%
  • MDL No. MFCD10699412
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆O₂
  • Molecular Weight 134.13
  • Synonym(s) 1-Benzofuran-5-ol
  • SMILES OC1=CC=C(OC=C2)C2=C1

Description

Benzofuran-5-ol delivers a robust heterocyclic scaffold with a strategically positioned hydroxyl group enabling direct functionalization. This electron-rich platform integrates readily into synthetic sequences requiring phenolic reactivity, offering enhanced stability under standard conditions for use in medicinal chemistry and materials development.

Application

Benzofuran-5-ol serves as a versatile building block in medicinal chemistry and materials science, offering a stable heterocyclic scaffold with a phenolic hydroxyl group at the 5-position. Its reactivity enables direct functionalization via electrophilic substitution, Suzuki coupling, or derivatization for pharmaceutical intermediates. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for scalable synthesis and downstream applications in API development.

Synthesis

  • Route1

    References

    • Bonini, Carlo; Cristiani, Graziella; Funicello, Maria; Viggiani, Licia Synthetic Communications, 2006 , vol. 36, # 14 p. 1983 - 1990
  • Route2
    • 2-Nitrofuran|CS-W016615
      609-39-2
    • null|null
      54125-02-9
    • ~50%
    • In-stock
      Benzofuran-5-ol|CS-W004630
      13196-10-6

    References

    • Rosa, Claudia Della; Kneeteman, Maria N.; Mancini, Pedro M.E. Tetrahedron Letters, 2005 , vol. 46, # 50 p. 8711 - 8714
  • Route3

    References

    • Synthetic Communications, , vol. 36, # 14 p. 1983 - 1990

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.37
  • LogP   2.1384
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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