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5-Bromo-2-(difluoromethyl)-1,3-thiazole

  • CAS No. 1319255-36-1

  • Cat. No. CS-0050637
  • Molecule weight214.03
  • Purity≥95%
  • MDL No.MFCD23106373

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-(difluoromethyl)-1,3-thiazole|CS-0050637

Structure of 1319255-36-1

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General Information

  • CAS No. 1319255-36-1
  • Cat. No. CS-0050637
  • Purity ≥95%
  • MDL No. MFCD23106373
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂BrF₂NS
  • Molecular Weight 214.03
  • Synonym(s) 5-Bromo-2-(difluoromethyl)thiazole
  • SMILES FC(F)C1=NC=C(Br)S1

Description

This difluoromethyl-substituted thiazole features a bromine atom at the 5-position, enabling direct functionalization in cross-coupling reactions. The electron-deficient heterocyclic core, combined with the fluorinated side chain, enhances metabolic stability and modulates lipophilicity for medicinal chemistry applications.

Application

5-Bromo-2-(difluoromethyl)-1,3-thiazole serves as a versatile building block for the synthesis of fluorinated heterocycles and pharmaceutical intermediates. The bromine substituent enables palladium-catalyzed cross-coupling reactions, while the difluoromethyl group imparts metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability, facilitates straightforward purification, and demonstrates broad functional group tolerance in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8432
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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