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Mal-amido-PEG5-C2-​NHS ester

  • CAS No. 1315355-92-0

  • Cat. No. CS-0105034
  • Purity≥98%
  • MDL No.MFCD20230002

*For research and further manufacturing use only, not for direct human use.

Mal-amido-PEG5-C2-​NHS ester|CS-0105034

Structure of 1315355-92-0

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General Information

  • CAS No. 1315355-92-0
  • Cat. No. CS-0105034
  • Purity ≥98%
  • MDL No. MFCD20230002
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₃₅N₃O₁₂
  • Molecular Weight 557.55
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O

Description

Mal-amido-PEG5-C2-NHS ester features a maleimide group conjugated to a PEG5 spacer with a C2 linker, enabling site-specific bioconjugation via thiol-reactive addition. The NHS ester moiety facilitates efficient coupling to primary amines under physiological conditions. This bifunctional reagent streamlines the creation of stable protein-drug conjugates and targeted delivery systems.

Application

Mal-amido-PEG5-C2-NHS ester serves as a versatile bifunctional crosslinker, enabling efficient conjugation of biomolecules via amine and thiol groups. The NHS ester reacts selectively with primary amines under physiological conditions, while the maleimide moiety rapidly engages cysteine thiols through Michael addition. This PEG5 spacer provides enhanced solubility and reduced non-specific binding, making it ideal for antibody-drug conjugates, protein labeling, and bioconjugation workflows requiring site-specific modification and improved stability.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   176.31
  • LogP   -1.502
  • H_Acceptors   12
  • H_Donors   1
  • Rotatable_Bonds   22

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