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CS-W001157 4
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Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate

  • CAS No. 1314538-55-0

  • Cat. No. CS-W006460
  • Purity≥95%
  • MDL No.MFCD19686142

*For research and further manufacturing use only, not for direct human use.

Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate|CS-W006460

Structure of 1314538-55-0

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General Information

  • CAS No. 1314538-55-0
  • Cat. No. CS-W006460
  • Purity ≥95%
  • MDL No. MFCD19686142
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂BF₃KNO₂
  • Molecular Weight 237.07
  • Synonym(s) Potassium (N-Boc-aminomethyl)trifluoroborate
  • SMILES CC(C)(OC(NC[B-](F)(F)F)=O)C.[K+]

Description

Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate delivers a stable, bench-ready source of the (Boc-amino)methyl group. This trifluoroborate ester enables efficient boron-based coupling reactions in peptide synthesis and chemical biology. The Boc-protected amine and trifluoroborate handle combine to offer enhanced stability and compatibility under standard reaction conditions.

Application

Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate serves as a stable, bench-friendly boron source for the synthesis of aminoalkylated heterocycles and peptide building blocks. It facilitates efficient Suzuki-Miyaura coupling reactions under mild conditions, enabling C–C bond formation with aryl and vinyl halides. The Boc-protected amine functionality offers orthogonal reactivity and simplifies purification, making it ideal for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Organic Letters, , vol. 13, # 15 p. 3956 - 3959

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   -1.0983
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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