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CS-W001157 4
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5-Fluorobenzofuran-6-carboxylic acid

  • CAS No. 1312556-72-1

  • Cat. No. CS-0043175
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluorobenzofuran-6-carboxylic acid|CS-0043175

Structure of 1312556-72-1

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General Information

  • CAS No. 1312556-72-1
  • Cat. No. CS-0043175
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅FO₃
  • Molecular Weight 180.13
  • Synonym(s) 5-Fluoro-1-benzofuran-6-carboxylic acid
  • SMILES O=C(C1=C(F)C=C2C=COC2=C1)O

Description

5-Fluorobenzofuran-6-carboxylic acid features a fluorinated benzofuran core with a carboxylic acid group at the 6-position, offering enhanced electron-withdrawing character and metabolic stability. This scaffold integrates readily into bioactive molecules, enabling efficient access to pharmaceutical intermediates and functional materials through coupling reactions under standard conditions.

Application

5-Fluorobenzofuran-6-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization reactions. Its fluorinated benzofuran scaffold imparts metabolic stability and favorable pharmacokinetic properties, while the carboxylic acid group facilitates direct derivatization or incorporation into peptide-like frameworks. The compound exhibits excellent bench stability and is compatible with common synthetic transformations, making it a practical choice for lead optimization and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.44
  • LogP   2.2701
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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