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CS-W001157 4
Total: USD 88.00

Ms-PEG2-C2-Boc

  • CAS No. 1312309-62-8

  • Cat. No. CS-0114569
  • Purity≥97%
  • MDL No.MFCD20926372

*For research and further manufacturing use only, not for direct human use.

Ms-PEG2-C2-Boc|CS-0114569

Structure of 1312309-62-8

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General Information

  • CAS No. 1312309-62-8
  • Cat. No. CS-0114569
  • Purity ≥97%
  • MDL No. MFCD20926372
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄O₇S
  • Molecular Weight 312.38
  • Synonym(s) None
  • SMILES CS(OCCOCCOCCC(OC(C)(C)C)=O)(=O)=O

Description

Ms-PEG2-C2-Boc features a protected amine handle at the terminus of a two-unit polyethylene glycol spacer, enabling efficient conjugation in bioconjugation workflows. The Boc group provides orthogonal protection, while the PEG linker enhances solubility and reduces aggregation during synthesis. This derivative supports modular peptide and biomolecule modification under standard conditions.

Application

Ms-PEG2-C2-Boc serves as a versatile bifunctional linker for peptide and biomolecule conjugation, combining the stability of a Boc-protected amine with a maleimide-tethered PEG spacer. The sulfonamide (Ms) group enables selective N-alkylation under mild conditions, while the PEG2 chain provides enhanced solubility and reduced aggregation. This reagent facilitates efficient conjugation to cysteine residues via Michael addition, offering excellent stability, ease of purification, and compatibility with standard synthetic workflows in medicinal chemistry and bioconjugate applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   88.13
  • LogP   0.7276
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   10

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