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CS-W001157 4
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1-(3-Chloropyridin-2-yl)ethanone

  • CAS No. 131109-75-6

  • Cat. No. CS-0052888
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Chloropyridin-2-yl)ethanone|CS-0052888

Structure of 131109-75-6

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General Information

  • CAS No. 131109-75-6
  • Cat. No. CS-0052888
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO
  • Molecular Weight 155.58
  • Synonym(s) 2-ACETYL-3-CHLOROPYRIDINE
  • SMILES CC(=O)C1=NC=CC=C1Cl

Description

1-(3-Chloropyridin-2-yl)ethanone features a chlorinated pyridine ring linked to a ketone group, delivering a reactive electrophilic center. This structure enables efficient coupling in cross-coupling reactions and serves as a key scaffold in medicinal chemistry. The compound exhibits stability under standard conditions and integrates readily into complex molecular architectures.

Application

1-(3-Chloropyridin-2-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing scaffolds via nucleophilic acyl substitution and palladium-catalyzed coupling reactions. Its chloro substituent enhances electrophilicity at the pyridine ring, facilitating further functionalization. The ketone group provides a handle for reductive amination or enolization-based transformations. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of API intermediates and heterocyclic libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.9376
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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