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CS-W001157 4
Total: USD 88.00

(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid

  • CAS No. 1308298-23-8

  • Cat. No. CS-D0474
  • Purity≥95%
  • MDL No.MFCD10696932

*For research and further manufacturing use only, not for direct human use.

(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid|CS-D0474

Structure of 1308298-23-8

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General Information

  • CAS No. 1308298-23-8
  • Cat. No. CS-D0474
  • Purity ≥95%
  • MDL No. MFCD10696932
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BF₃N₂O₂
  • Molecular Weight 191.90
  • Synonym(s) 2-(trifluoromethyl)pyrimidin-5-ylboronic acid
  • SMILES OB(C1=CN=C(C(F)(F)F)N=C1)O

Description

This boronate moiety features a trifluoromethylpyrimidine scaffold, delivering enhanced metabolic stability and electron-deficient character. It integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, enabling efficient access to functionalized heteroaryl architectures in medicinal chemistry and materials science.

Application

(2-(Trifluoromethyl)pyrimidin-5-yl)boronic acid serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biologically relevant pyrimidine derivatives. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the boronic acid functionality facilitates reliable Suzuki-Miyaura coupling under standard conditions. The compound exhibits excellent bench stability, ease of handling, and compatibility with diverse functional groups, making it ideal for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.24
  • LogP   -0.8248
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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