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CS-W001157 4
Total: USD 88.00

N-alpha-Fmoc-D-Arginine

  • CAS No. 130752-32-8

  • Cat. No. CS-0062084
  • Molecule weight396.44
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-alpha-Fmoc-D-Arginine|CS-0062084

Structure of 130752-32-8

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General Information

  • CAS No. 130752-32-8
  • Cat. No. CS-0062084
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₄N₄O₄
  • Molecular Weight 396.44
  • Synonym(s) Fmoc-D-Arg-OH
  • SMILES N=C(N)NCCC[C@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Description

N-alpha-Fmoc-D-Arginine features a D-configured arginine residue protected at the alpha-amino group with a fluorenylmethoxycarbonyl (Fmoc) moiety. This configuration enables efficient incorporation into peptide chains during solid-phase synthesis, offering enhanced stability and reduced racemization risk compared to L-isomers. The Fmoc group facilitates orthogonal deprotection under mild basic conditions, streamlining sequence assembly in complex peptide architectures.

Application

N-alpha-Fmoc-D-Arginine serves as a key building block in solid-phase peptide synthesis, enabling efficient incorporation of D-arginine residues into peptide sequences. The Fmoc group provides orthogonal protection compatible with standard deprotection protocols, while the side-chain guanidine functionality remains stable under routine coupling conditions. This derivative facilitates synthesis of bioactive peptides and peptidomimetics with enhanced metabolic stability and protease resistance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   137.53
  • LogP   2.24157
  • H_Acceptors   4
  • H_Donors   5
  • Rotatable_Bonds   8

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