N-alpha-Fmoc-D-Arginine

Name: N-alpha-Fmoc-D-Arginine
Brand: ChemScene
Availability: InStock
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CAS No. 130752-32-8
Cat. No. CS-0062084
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 130752-32-8

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Description

N-alpha-Fmoc-D-Arginine features a D-configured arginine residue protected at the alpha-amino group with a fluorenylmethoxycarbonyl (Fmoc) moiety. This configuration enables efficient incorporation into peptide chains during solid-phase synthesis, offering enhanced stability and reduced racemization risk compared to L-isomers. The Fmoc group facilitates orthogonal deprotection under mild basic conditions, streamlining sequence assembly in complex peptide architectures.

Application

N-alpha-Fmoc-D-Arginine serves as a key building block in solid-phase peptide synthesis, enabling efficient incorporation of D-arginine residues into peptide sequences. The Fmoc group provides orthogonal protection compatible with standard deprotection protocols, while the side-chain guanidine functionality remains stable under routine coupling conditions. This derivative facilitates synthesis of bioactive peptides and peptidomimetics with enhanced metabolic stability and protease resistance.

General Information

CAS No. 130752-32-8
Cat. No. CS-0062084
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₄N₄O₄
Molecular Weight 396.44
Synonym(s) Fmoc-D-Arg-OH
SMILES N=C(N)NCCC[C@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O

Computational Chemistry Data

TPSA 137.53
LogP 2.24157
H_Acceptors 4
H_Donors 5
Rotatable_Bonds 8

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Guanidine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Arginine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids N-Protected Amino Acids

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N-alpha-Fmoc-D-Arginine

CAS No. 130752-32-8

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