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CS-W001157 4
Total: USD 88.00

(Tetrahydro-2H-pyran-4-yl)methanamine

  • CAS No. 130290-79-8

  • Cat. No. CS-W008973
  • Purity≥97%
  • MDL No.MFCD02179435

*For research and further manufacturing use only, not for direct human use.

(Tetrahydro-2H-pyran-4-yl)methanamine|CS-W008973

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General Information

  • CAS No. 130290-79-8
  • Cat. No. CS-W008973
  • Purity ≥97%
  • MDL No. MFCD02179435
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO
  • Molecular Weight 115.17
  • Synonym(s) tetrahydropyran-4-ylmethanamine
  • SMILES NCC1CCOCC1

Description

(Tetrahydro-2H-pyran-4-yl)methanamine features a protected amine tethered to a tetrahydropyran ring, offering enhanced stability and solubility in polar organic media. This scaffold integrates readily into complex molecular architectures, serving as a key building block in medicinal chemistry and peptide derivatization workflows.

Application

(Tetrahydro-2H-pyran-4-yl)methanamine serves as a versatile, bench-stable building block for the synthesis of bioactive heterocycles and functionalized amine derivatives. Its tetrahydropyranyl ether moiety provides orthogonal protection for alcohols, while the primary amine enables straightforward conjugation via standard amidation or alkylation protocols. The molecule exhibits excellent functional group tolerance and facilitates efficient purification due to its solubility profile, making it well-suited for medicinal chemistry campaigns and scalable process development.

Synthesis

  • Route1

    References

    • EP1671937 A1, ; Page/Page column 16-17 ;
  • Route2

    References

    • WO2004/58759 A1, ; Page 284 ;
  • Route3

    References

    • Justus Liebigs Annalen der Chemie, , vol. 535, p. 37,45

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.3717
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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