Lot numbers can be found on the outside label of a product:
2-Hydroxy-2-methylpropanamide
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CAS No. 13027-88-8
- Cat. No. CS-0154975
- Purity≥97%
- MDL No.MFCD08063365
*For research and further manufacturing use only, not for direct human use.
Structure of 13027-88-8
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General Information
- CAS No. 13027-88-8
- Cat. No. CS-0154975
- Purity ≥97%
- MDL No. MFCD08063365
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₉NO₂
- Molecular Weight 103.12
- Synonym(s) Propanamide, 2-hydroxy-2-methyl-
- SMILES CC(C(N)=O)(O)C
Description
2-Hydroxy-2-methylpropanamide is a bench-stable, moisture-tolerant amide featuring a tertiary carbon bearing both hydroxyl and carbonyl functionalities. This structural motif enables direct incorporation into peptide mimetics and bioactive scaffolds, offering enhanced solubility and resistance to racemization during coupling reactions.
Application
2-Hydroxy-2-methylpropanamide serves as a stable, bench-ready synthon for the introduction of hydroxyl and amide functionalities in complex molecule synthesis. Its tertiary alcohol moiety enables direct functionalization or derivatization under mild conditions, while the amide group provides excellent stability and solubility in polar solvents. This compound facilitates efficient access to β-hydroxy amide motifs commonly found in bioactive scaffolds and peptide analogs.
Synthesis
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Route1
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75-86-5 - ~96%
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In-stock
13027-88-8
References
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Zil'berman, E. N.; Eremeev, I. V. Russian Journal of Physical Chemistry, 1984 , p. 471 - 472 Zhurnal Fizicheskoi Khimii, 1984 , vol. 58, # 3 p. 772 - 775
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Route2
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110434-78-1
- ~83%
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In-stock
13027-88-8
References
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Schwarz, Gabriele; Geffken, Detlef Liebigs Annalen der Chemie, 1988 , p. 35 - 38
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Route3
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75-86-5
- ~%
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49562-37-0
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In-stock
13027-88-8
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In-stock
79-39-0
References
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US2006/111586 A1, ; Page/Page column 5-6; 8 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364
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Quality Control
Computational Chemistry Data
- TPSA 63.32
- LogP -0.7574
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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