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tert-Butyl (1H-pyrazol-4-yl)carbamate

  • CAS No. 130106-42-2

  • Cat. No. CS-0047043
  • Purity≥97%
  • MDL No.MFCD12133944

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (1H-pyrazol-4-yl)carbamate|CS-0047043

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General Information

  • CAS No. 130106-42-2
  • Cat. No. CS-0047043
  • Purity ≥97%
  • MDL No. MFCD12133944
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃N₃O₂
  • Molecular Weight 183.21
  • Synonym(s) tert-butyl N-(1H-pyrazol-4-yl)carbamate
  • SMILES O=C(OC(C)(C)C)NC1=CNN=C1

Description

tert-Butyl (1H-pyrazol-4-yl)carbamate serves as a stable, bench-ready protecting group for primary amines in pyrazole-based syntheses. This carbamate derivative facilitates efficient coupling reactions and selective deprotection under mild acidic conditions, enabling streamlined access to functionalized pyrazole intermediates in medicinal chemistry and agrochemical development.

Application

tert-Butyl (1H-pyrazol-4-yl)carbamate serves as a stable, bench-friendly protecting group for primary amines in pyrazole-based scaffolds. It enables selective functionalization at the 4-position of the pyrazole ring and facilitates downstream coupling reactions via mild deprotection. The carbamate functionality exhibits excellent compatibility with diverse reaction conditions, including Pd-catalyzed cross-couplings and electrophilic substitutions, making it a practical building block for medicinal chemistry and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.01
  • LogP   1.7567
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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