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CS-W001157 4
Total: USD 88.00

Benzo[cd]indol-2(1H)-one

  • CAS No. 130-00-7

  • Cat. No. CS-0046300
  • Purity≥95%
  • MDL No.MFCD00009748

*For research and further manufacturing use only, not for direct human use.

Benzo[cd]indol-2(1H)-one|CS-0046300

Structure of 130-00-7

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General Information

  • CAS No. 130-00-7
  • Cat. No. CS-0046300
  • Purity ≥95%
  • MDL No. MFCD00009748
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇NO
  • Molecular Weight None
  • Synonym(s) Naphthostyril
  • SMILES O=C1NC2=C3C1=CC=CC3=CC=C2

Description

Benzo[cd]indol-2(1H)-one delivers a rigid, planar heterocyclic scaffold ideal for probing biological activity in kinase inhibition and receptor binding studies. This electron-deficient core integrates seamlessly into complex molecular architectures, offering enhanced metabolic stability and favorable π-stacking interactions in target engagement.

Application

Benzo[cd]indol-2(1H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to complex indole-based architectures. Its stable, planar structure facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions, while the lactam functionality offers hydrogen-bonding capability and enhanced solubility. The compound demonstrates excellent bench stability and compatibility with standard purification protocols, making it a practical building block for API development and library synthesis.

Synthesis

  • Route1
    • null|null
      5551-72-4
    • ~95%
    • In-stock
      Benzo[cd]indol-2(1H)-one|CS-0046300
      130-00-7

    References

    • ADEKA CORPORATION Patent: US2011/152538 A1, 2011 ; Location in patent: Page/Page column 22; 26 ;
  • Route2
    • null|null
      95-50-1
    • null|null
      86-84-0
    • ~79%
    • In-stock
      Benzo[cd]indol-2(1H)-one|CS-0046300
      130-00-7

    References

    • Bayer Aktiengesellschaft Patent: US4152330 A1, 1979 ;
  • Route3
    • null|null
      86-84-0
    • ~%
    • In-stock
      Benzo[cd]indol-2(1H)-one|CS-0046300
      130-00-7

    References

    • Zhurnal Obshchei Khimii, , vol. 23, p. 798; engl. Ausg. S. 835

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H411-H319
Precautionary Statements : P264-P273-P280-P305+P351+P338-P337+P313-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.4055
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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