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CS-W001157 4
Total: USD 88.00

1-(2-Aminoethyl)piperidin-4-ol

  • CAS No. 129999-60-6

  • Cat. No. CS-0067956
  • Purity≥95%
  • MDL No.MFCD04038390

*For research and further manufacturing use only, not for direct human use.

1-(2-Aminoethyl)piperidin-4-ol|CS-0067956

Structure of 129999-60-6

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General Information

  • CAS No. 129999-60-6
  • Cat. No. CS-0067956
  • Purity ≥95%
  • MDL No. MFCD04038390
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂O
  • Molecular Weight 144.22
  • Synonym(s) None
  • SMILES OC1CCN(CCN)CC1

Description

1-(2-Aminoethyl)piperidin-4-ol features a primary amine pendant on a piperidin-4-ol scaffold, combining basic nitrogen functionality with a hydroxyl group. This bifunctional architecture enables robust coordination in metal-ligand systems and enhances solubility in polar solvents. The molecule exhibits excellent stability under standard bench conditions and serves as a key building block for bioactive heterocycles and functional polymers.

Application

1-(2-Aminoethyl)piperidin-4-ol serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of complex nitrogen-containing scaffolds. Its primary amine and secondary alcohol functionalities offer orthogonal reactivity for conjugation and derivatization. The molecule exhibits good bench stability and facilitates efficient purification, making it well-suited for use in peptide coupling, macrocyclization, and targeted library synthesis.

Synthesis

  • Route1
    • 2-(4-Hydroxypiperidin-1-yl)acetonitrile|CS-0726256
      78503-67-0
    • ~44%
    • In-stock
      1-(2-Aminoethyl)piperidin-4-ol|CS-0067956
      129999-60-6

    References

    • Pors, Klaus; Plumb, Jane A.; Brown, Robert; Teesdale-Spittle, Paul; Searcey, Mark; Smith, Paul J.; Patterson, Laurence H. Journal of Medicinal Chemistry, 2005 , vol. 48, # 21 p. 6690 - 6695
  • Route2
    • null|null
      5382-16-1
    • ~%
    • In-stock
      1-(2-Aminoethyl)piperidin-4-ol|CS-0067956
      129999-60-6

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 21 p. 6690 - 6695

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.49
  • LogP   -0.5982
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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